By Patrick Arnold SERM stands for selective estrogen receptor modulator. Also known as estrogen receptor agonist/ antagonists (or anti-estrogens), these drugs are used by bodybuilders to block the estrogenic effects of anabolic steroids and/or to help stimulate the production of natural testosterone after a steroid cycle. Examples of SERMs are tamoxifen (Nolvadex), clomiphene (Clomid), and raloxifene (Evista). These drugs work at the estrogen receptor to block the effects of estrogen in certain areas of the body (such as the central nervous system and breast) while in other parts of the body (bone, liver) they act as active estrogens. Their antagonist properties at the breast make them useful in avoiding or treating anabolic steroid induced gynecomastia, while at the hypothalamus/pituitary the anti-estrogen action helps to block the suppressive effect of estrogens upon luteinizing hormone production (and hence testosterone production). Lately, some people have explored using SERMs as an alternative to testosterone replacement therapy. Indeed they do work to stimulate testosterone production in most males and they can restore healthy levels to guys who have lower than normal testosterone blood readings. Editors Note: I am extremely pleased to have Bill Llewellyn contributing an article for us this week. For those who are unaware, he is the author of Anabolics 2000 and Anabolics 2002 and is one of the bodybuilding world’s foremost experts on androgens and anabolics. He is also the President of Molecular Nutrition, one of the most innovative companies in this business. Along with Avant Labs and Ergo Pharm, Molecular Nutrition is one of the few companies dedicated to putting forth only those products backed by legitimate research, rather than excessive hype and other such B. Two products, in particular, that deserve to be more well-known are Viritase, a potent anti-estrogen, and Boldione, a boldenone precursor. To find out more about these, and the rest of their products, I reccomend that you head over to their website — but only after you have finsished reading big Mf’r and spent all of your money on our products, of course 🙂 Now, on to the article: I have received a lot of heat lately about my preference for Nolvadex over Clomid, which I hold for all purposes of use (in the bodybuilding world anyway); as an anti-estrogen, an HDL (good) cholesterol-supporting drug, and as a testosterone-stimulating compound. Most people use Nolvadex to combat gynecomastia over Clomid anyway, so that is an easy sell. And for cholesterol, well, most bodybuilders unfortunately pay little attention to this important issue, so by way of disinterest, another easy opinion to discuss. How to buy kamagra online Buy generic cialis from uk On the course there is a sharp increase in sexual desire. Testosterone Steroid Profile. Tamoxifen Balkan Tamoxifen / Kalpa Tamoxifen / Dragon Pharma Tamoxifen or Clomiphene Balkan Clomiphene / Dragon Pharma Clomiphene / Kalpa Clomiphene. Powerful Sustanon Cycle for Bulking Clomid, Nolvadex, and Testosterone Stimulation Editors Note I am extremely pleased to have Bill Llewellyn contributing an article for us this week. For those who are. Bird CE, Masters V, Sterns EE, Clark AF. Testosterone is a known estrogen precursor especially in postmenopausal women. Tamoxifen, an anti-estrogen, is. Reggie Johal is the founder of Predator Nutrition, a UK based health and supplement store. Reggie owes much of his extensive strength and fitness knowledge to his former career as a Great Britain American Footballer. Nolvadex (tamoxifen) is a SERM (Selective Estrogen Receptor Modulator) from the same class of medications that Clomid is in. Clomid is widely used by men to boost testosterone (and improve fertiliy) and, as of this writing, about 8% of the men who took a Peak Testosterone poll on T-boosting therapies were on Clomid. That works out to about one out of every thirteen men. SERMs are very convenient, generally inexpensive and (in most men) help keep the testicles fully functional and active. They work by inhibiting negative feedback at the hypothalamus and so, for men with a working hypothalamus and pituitary, are a pretty well-accepted way to bring the testes back online. Nolvadex uniquely has a couple of other nice advantages: it can help some men with gynocomastia and possibly elevated prolactin. (See my page on Tamoxifen and Prolactin for more information.) It does the former due to the fact it has some anti-estrogen properties. Unfortunately, that has never been studied thoroughly. 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