Although it is uncommon, lupus can also attack a patient’s liver, causing a more pronounced elevation in liver enzymes, such as ASTs and ALTs. When this happened to me, my symptoms included pervasive malaise, nausea, itching, and worsening of my overall health and lupus activity. Plaquenil and teeth Side effects of plaquenil and methotrexate A very serious allergic reaction to this drug is rare. However, get medical help right away if you notice any symptoms of a serious allergic reaction, including rash, itching/swelling especially of the face/tongue/throat, dizziness, trouble breathing. This is not a complete list of possible side effects. Several risk factors may increase the likelihood of retinal toxicity from Plaquenil such as, age of greater than 60 years, daily dose more than 6.5 mg/kg; use of the drug more than 5 years, obesity, preexisting retinal disease and, renal or liver failure. Liver infections Hepatitis A; Hepatitis B; Hepatitis C; Issues with the immune system may cause attacks on the liver causing Primary biliary cirrhosis; Autoimmune hepatitis; Primary sclerosing cholangitis 1,2 Fatty liver. Alcoholic liver disease ALD-specific early symptoms are abdominal pain, feeling sick, fatigue, feeling unwell, and decrease in appetites. Specific late symptoms are jaundice, swelling of extremities, fever, and itchy skin. They consulted and referred me to a gastroenterologist. My family doctor was persistent in finding an answer, and wouldn’t let my rheumatologist rest until they found one. Is plaquenil processed through the liver Antibiotics and the liver. Only one group is liver friendly - Hepatitis., The Risk of Retinal Toxicity with Plaquenil - Sjogren's Chloroquine phosphate tablets 250 mg dosage Plaquenil is very effective for the symptoms of achiness and fatigue. However, there might be a price to pay in terms of retinal toxicity especially after taking it for as long as you have. Given that the alopecia had developed while you were on the plaquenil, it's not clear that going back on it will help that symptom much. PLAQUENIL To Take or Not To Take?" Lupus Community.. Liver Pain - Location, Causes, Symptoms and Treatment - 2020.. What processes does the liver undergo to remove toxins? disposal of toxins. Plaquenil has never raised my liver enzymes and I have been on it for six years. The only time my ALT and AST were elevated when I was taking too much iron supplements for my anemia. Once I stopped those, the enzymes went back to normal. Yes, plaquenil is difficult to adjust first, but after the first year of treatment and side effects, the benefits outweigh the problems. So, stick with it. In my opinion, the plaque nil is keeping the immune system regulated and the pain and other symptoms described will reduce. Lupus is not an illness without pain or sacrifice, but, it’s worth it. The liver is located in the upper right-hand portion of the abdominal cavity, beneath the diaphragm, and on top of the stomach, right kidney, and intestines. Shaped like a cone, the liver is a dark reddish-brown organ that weighs about 3 pounds. There are 2 distinct sources that supply blood to the.