Clinical question: Are clinical outcomes for dexamethasone equivalent to currently recommended corticosteroids for the treatment of children with mild to moderate asthma exacerbations? Background: National and international guidelines uniformly agree that administration of a systemic corticosteroid is appropriate for children hospitalized with mild to moderate asthma exacerbations. Based on available literature, a 2007 update to an expert panel report developed by the National Asthma Education and Prevention Program recommended prednisone, methylprednisolone, or prednisolone at 1-2 mg/kg daily in two divided doses (maximum 60 mg/day). Recent small studies have begun to examine the use of dexamethasone in acute asthma exacerbations. The longer half-life of dexamethasone enables shorter treatment regimens, which can improve compliance. Additionally, its taste is considered superior compared to currently recommended corticosteroids. Study designs: Two meta-analyses of randomized controlled trials (RCT). Synopsis: Both groups searched Medline for RCTs using the search terms “dexamethasone” and “asthma”; additional search terms included “decadron” and “status asthmaticus.” Limiting the search to a pediatric population was achieved by either using appropriate medical subject heading terms or by using an age limiter of ≤18 years of age. Last year my doctor prescribed me with Prednisolone to treat my rheumatoid arthritis. Both my knees are badly affected by the disease and it is a real suffering for me to move sometimes, after a long period without movement I can not easily get up and walk. I have to rub my knees, get used to the pain, and wait for the pain to fade away. It takes me about an hour to get out of my bedroom as I have to do many exercises before I stand up and can make first steps. The disease has been torturing me for more than seven years in general. 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