Duloxetine for back pain

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  1. seokus XenForo Moderator

    Duloxetine for back pain


    In late 2010, the FDA announced that it had approved duloxetine for the treatment of musculoskeletal pain, including chronic lower back pain ( The approval was based on data from “four double-blind, placebo-controlled, randomized clinical trials” in which investigators assessed the efficacy of Cymbalta in chronic low back pain and osteoarthritis. The FDA statement announcing approval of Cymbalta for this indication noted that “at the end of the study period, patients taking Cymbalta had a significantly greater pain reduction compared with placebo.” Although a recent overview of the available data noted that several trials have been of “short duration (12-13 weeks) and had high dropout rates” ( I), results on the efficacy of duloxetine in this patient population have generally been favorable. Placebo in Patients with Chronic Low Back Pain: A 12- Week, Fixed-dose, Randomized, Double-blind Trial” ( Sf V), researchers treated more than 400 adults with non-neuropathic chronic low back pain with duloxetine or placebo for 12 weeks. Participants all reported a pain intensity of 4 or greater on the Brief Pain Inventory (BPI) at baseline. After 12 weeks of treatment, patients who had received duloxetine reported a significantly greater reduction in average pain intensity scores (measured by BPI) compared to patients who received placebo. The duloxetine group also reported significantly greater improvements in Patient’s Global Impressions of Improvement measures, pain severity and interference (as measured by BPI), and 50% response rates (average BPI pain reduction of 50% or more at endpoint). Patients in the duloxetine group also reported better scores on the Roland Morris Disability Questionnaire and had improved 30% response rates. Patients treated with duloxetine for chronic low back pain (CLBP) with multiple painful sites had more benefit than patients with isolated CLBP, and early pain reduction was predictive of response for all patients. This according to a recent post hoc responder analysis of 4 double-blind, randomized, placebo-controlled trials of duloxetine (60 mg/day for 12-14 weeks) in adults patients with CLBP. Primary outcome was proportion of patients with ≥30% reduction in Brief Pain Inventory (BPI) average pain at 12-14 weeks. The proportion of patients with ≥30% and ≥50% (secondary outcome) pain reduction in duloxetine and placebo groups was compared. Treatment typically includes analgesics such as acetaminophen, NSAIDs, opioids, and adjuvant pain medications, as well as physical modalities including stretching, exercise, and physical therapy. With increased recognition of the side effects of NSAIDs, and risks of addiction with opioids, the use of adjuvant pain medications like duloxetine has become increasingly sigificant. One theory holds that a significant number of patients with CLBP have pain secondary to changes in the central nervous system processing of pain. If patients who are likely to have central sensitization as an important contributor to their pain can be identified ahead of time, then we might have a higher chance of effectively treating their pain with adjuvant pain medications, including duloxetine.

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    Cymbalta Duloxetine For Back Pain Cymbalta, the trade name for duloxetine, is an antidepressant medication that is widely used in the management of anxiety and clinical depression. However, its applications do not end there and off late, Cymbalta has been used in the management of musculoskeletal pain, particularly back pain. Sep 4, 2018. A 2010 study found that a daily dose of Cymbalta significantly reduced chronic low back pain, compared to a placebo. Read this article for an. Cymbalta will help with nerve pain in higher dose's, im on 180mg per day for depression and pain, it works great with dep. and not real well for pain. But sometimes we do get pain from deperrsion. But sometimes we do get pain from deperrsion.

    Among patients with chronic low back pain (CLBP), approximately 37% show signs of a neuropathic pain component (radicular pain). Therefore, the current study aimed to investigate the efficacy of duloxetine in the treatment of CLBP patients with neuropathic leg pain. The study was conducted as a prospective, randomized, placebo-controlled, double-blind crossover trial. CLBP with a visual analog scale (VAS) score greater than 5 and a neuropathic component that was assessed clinically and by the pain DETECT questionnaire (score 12) were required for inclusion. Patients were randomly assigned to either duloxetine or placebo for 4 weeks followed by a 2-week washout period before they crossed over to the alternate phase that lasted another 4 weeks. The primary outcome parameter was mean VAS score during the last week of treatment in each phase (VASIn this randomized, placebo-controlled crossover trial, patients with radicular symptoms experienced an average 32% reduction in pain after 4 weeks of treatment with duloxetine. The overall adverse event rate was similar between placebo and duloxetine treatments. It is also referred to as projected pain, which is caused by damage or irritation of peripheral nerves or nerve roots. However, radicular pain may also be triggered by local inflammatory processes that are caused by disc degeneration, even without verifiable mechanical compression. In a large, placebo-controlled 13-week trial, duloxetine led to a statistically significant pain reduction between weeks 3 and 11. Importantly, in all the aforementioned randomized controlled trials, CLBP patients with a neuropathic pain component were explicitly excluded. The findings, which were presented at the American Academy of Pain Medicine's Annual Meeting in February 2010, were based on results from the Brief Pain Inventory (BPI). The BPI is a scientific tool used to rate a patient's degree of pain. In this experiment, researchers studied 401 patients with chronic low back pain. Over the course of 3 months, one group of patients received a 60-mg dose of Cymbalta, while the other group received a placebo. The patients in the Cymbalta group reported a significant reduction in their pain, compared to the placebo group. However, the researchers also noted that Cymbalta's negative side effects caused 30 of the 198 patients in the Cymbalta group to drop out of the study. These common side effects include nausea, headache, and dizziness.

    Duloxetine for back pain

    Duloxetine for Chronic Pain Conditions Recommendations for., Cymbalta May Reduce Chronic Low Back Pain - SpineUniverse

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  7. Duloxetine also appeared to work faster, in general, for neuropathic pain patients, with a median time to therapeutic dose TTD of 7 days 0-44.25, IQR. 2 This was significantly different from venlafaxine titrations, which had a median TTD of 31.5 days 10-115, IQR.

    • Duloxetine More Effective at Treating Neuropathic Pain.
    • Cymbalta for nerve pain - MedHelp.
    • Duloxetine 60 mg for chronic low back pain post hoc..

    Feb 5, 2010. A new study shows people with chronic low back pain treated with Cymbalta experienced a significantly greater improvement in average pain. Aug 22, 2017. Patients treated with duloxetine for chronic low back pain CLBP with multiple painful sites had more benefit than patients with isolated CLBP. Cymbalta duloxetine is a selective serotonin and norepinephrine reuptake inhibitor SNRI used for treating depression, anxiety disorder, and pain associated with diabetic peripheral neuropathy or fibromyalgia.

     
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