Use of chloroquine during pregnancy

Discussion in 'Canadian Pharcharmy' started by Den24, 07-Mar-2020.

  1. Comad XenForo Moderator

    Use of chloroquine during pregnancy

    While the mechanism is poorly understood, pregnant women have a reduced immune response and therefore less effectively clear malaria infections. In addition, malaria parasites sequester and replicate in the placenta.

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    The use of chloroquine during pregnancy. Brain SD1, de Silva HA, Walker B. Author information 1Division of Biomedical Sciences, Kings College, London. Chloroquine has not been formally assigned to a pregnancy category by the FDA. There are no controlled data in human pregnancies. Congenital anomalies were reported in the offspring of one woman being treated with chloroquine 250 to 500 mg daily during pregnancy for SLE; however, chloroquine has been used in the prophylaxis and treatment of malaria during pregnancy without evidence of fetal harm. Hydroxychloroquine Pregnancy Warnings Animal studies have revealed evidence of fetal harm. Use of chloroquine and other 4-aminoquinolines in high doses and for prolonged durations has been associated with neurological disturbances and interference with hearing, balance, and vision in the fetus. There are no controlled data in human pregnancy.

    Malaria infection during pregnancy can lead to miscarriage, premature delivery, low birth weight, congenital infection, and/or perinatal death. Pregnant women are three times more likely to develop severe disease than non-pregnant women acquiring infections from the same area.

    Use of chloroquine during pregnancy

    Antimalarial drugs and pregnancy safety, pharmacokinetics., Chloroquine Use During Pregnancy

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  7. Chloroquine, although grouped with hydroxychloroquine in table 2 of this article, is not routinely used in the management of SLE either in or out of pregnancy due to increased tissue deposition and increased risk of retinal toxicity and of fetal

    • Treatment of SLE in pregnancy and use of Chloroquine The BMJ.
    • Hydroxychloroquine Use During Pregnancy.
    • Chloroquine Aralen - Side Effects, Dosage, Interactions..

    Anti-malarial drugs hydroxychloroquine, chloroquine are considered pregnancy category C drugs. While there is evidence of risk for damage to the eye and ear, if the benefits of these drugs in controlling RA symptoms are judged to outweigh the risks, they may continue to be used during pregnancy. 1,2. Biologics It appears to be safe for use during pregnancy. It works against the asexual form of malaria inside the red blood cell. Chloroquine was discovered in 1934 by Hans Andersag. It is available as a generic medication. Usage in Pregnancy. Usage of chloroquine during pregnancy should be avoided except in the prophylaxis or treatment of malaria when the benefit outweighs the potential risk to the fetus. Radioactively tagged chloroquine administered intravenously to pregnant pigmented CBA mice passed rapidly across

  8. Cheriksoft Guest

    Plaquenil (hydroxychloroquine) belongs to a group of medicines called quinolines. Plaquenil Side Effects Common, Severe, Long Term - Hydroxychloroquine Oral Route Side Effects - Mayo Clinic What Causes Bleeding Gums Gum Disease & Gingivitis Effects
  9. stabilo Well-Known Member

    Compare Qualaquin vs Plaquenil - Plaquenil hydroxychloroquine has been shown to improve physical function in up to 80% of patients with rheumatoid arthritis. Plaquenil hydroxychloroquine is commonly used for lupus in children because of less side effects compared to other medications. Plaquenil hydroxychloroquine helps minimize joint damage.

    Chloroquine vs Hydroxychloroquine Comparison -