I've been on plaquenil for 6 months for suspected Sjogren's syndrome (I don't have antibodies for Sjorgren's or Lupus but I do have Hashimoto's and have all the symptoms for Sjorgren's so the rheumatologist suggested a trial of plaquenil). Basically I've been on the drug since January and saw the rheumatologist on Wednesday to see how things are going. Hydroxychloroquine hypertension Chloroquine storage temp Hero study hydroxychloroquine I reduced my dosage to 200mg instead of 400mg instead of to just stop taking it. Plaquenil was amazing the first 2 mths I used it, it stopped the fatigue for the most part, stopped my pain. Then it just all came flooding back. don't want to take plaquenil anymore. FYI.probably need to give the plaquenil more time. And take the. If you don't have to, don't stop your plaquenil. I stopped taking the plaquenil the beginning of December. It doesn't agree with my stomach I take it with meals too. And since I hadn't had a miraculous recovery the 6 months I'd been on it, I didn't think there was any harm in stopping it. Taking Plaquenil long-term or at high doses may cause irreversible damage to the retina of your eye. Stop taking Plaquenil and call your doctor at once if you have trouble focusing, if you see light streaks or flashes in your vision, or if you notice any swelling or color changes in your eyes. I do think it's helped with fatigue and muscle pain but it's hard for me to compare to Xmas as when the improvement is so gradual I think it's really hard to notice on a gradual basis. I *think* I'm improving but it's been a gradual process and I said to him that it's quite hard to tell how much of an improvement I'm feeling. How do i stop taking plaquenil Let me tell you what weaning down from Plaquenil is like., Stopping plaquenil. DailyStrength Plaquenil pulmonary toxicity Taking hydroxychloroquine long-term or at high doses may cause irreversible damage to the retina of your eye. Stop taking hydroxychloroquine and call your doctor at once if you have trouble focusing, if you see light streaks or flashes in your vision, or if you notice any swelling or color changes in your eyes. Call your doctor at once if you have Plaquenil Hydroxychloroquine Side effects, Images, Uses.. Plaquenil Uses, Dosage & Side Effects -. Plaquenil Withdrawal – Life As An Anomaly. SIDE EFFECTS. The following adverse reactions have been identified during post-approval use of PLAQUENIL or other 4-aminoqunoline compounds. Because these reactions are reported voluntarily from a population of uncertain size, it is not always possible to reliably estimate their frequency or establish a causal relationship to drug exposure. One of the reasons that physicians feel comfortable in prescribing Plaquenil is its low risk to benefit ratio. This means that the side effects of Plaquenil are mild and infrequent compared with its potential benefits. As with any medication, allergic reactions including skin rashes and non-allergic reactions can occur. Plaquenil is a 6-weeker as far as the benefits are concerned, but it would be more dangerous to stop if you spend a lot of time outside and if this were the summer. If you're gonna experiment, I went off it cold turkey as it didn't hurt to do it that way, but you better get back on before the summer or you could experience a flare-up.