Pattern of Retinopathy: Although the locus of toxic damage is parafoveal in many eyes, Asian patients often show an extramacular pattern of damage. Dose: We recommend a maximum daily HCQ use of 5.0 mg/kg real weight, which correlates better with risk than ideal weight. Chloroquine mechanism Hydroxychloroquine use during pregnancy Chances of having a lupus flare when stopping plaquenil Plaquenil. SO MUCH LOVE. The most common side effects are nausea and diarrhea, which often improve with time or by taking the medication with food. Less common side effects include skin rashes, changes in skin pigment such as darkening or dark spots, hair changes bleaching or thinning of hair, and weakness. Rarely, hydroxychloroquine can Macular Society Eye screening for patients taking hydroxychloroquine. Hydroxychloroquine is a medication used to treat several conditions including rheumatoid arthritis, systemic lupus erythematosus, some skin conditions especially photosensitive ones and others that involve inflammation. The actual incidence of retinal toxicity from hydroxychloroquine is difficult to pin down because there is usually a long time between being started on the drug and the start of any identifiable retinal toxicity. The overall rate of probable retinal toxicity is in the range of 1 of every 200 people treated. Risk of Toxicity: The risk of toxicity is dependent on daily dose and duration of use. There are no similar demographic data for CQ, but dose comparisons in older literature suggest using 2.3 mg/kg real weight. Eye test for plaquenil toxicity Hydroxychloroquine Plaquenil Toxicity and., Eye screening for patients taking hydroxychloroquine Plaquenil Hypoglycemia due to maternal plaquenilChloroquine topicalChloroquine disposal This occurs when melanin is able to bind to the “High Risk Medication” Plaquenil within the Retinal Pigment Epithelium RPE as well as direct toxicity to retinal ganglion cells. The drugs ability to bind to these pigmented cells creates a “Bulls Eye” around the macula, giving it this very unique appearance. Dr. Noskow's Case Report Plaquenil Toxicity - Hollywood Eye Institute. What can Hydroxychloroquine Plaquenil do to my eyes?. Plaquenil Toxicity Screening - Retina Group of New York. Good question. Back on nov 5 i think it was i felt there was a really good discussion about hydroxychlorouine & eye tests here. One of us posted detailed info about her experience & the different types of eye test anyone on plaquenil etc would probably be best to have, and the frequency. Eye screening for patients taking hydroxychloroquine Plaquenil® This leaflet contains important information for people taking hydroxychloroquine. This leaflet is available on audio CD. You don’t have to face macular disease alone. For the best information and support call us on 0300 3030 111. Once retinal toxicity from hydroxychloroquine occurs, it is thought that the retinal changes are permanent and the disease can progress even if hydroxychloroquine is stopped for 1 to 3 years. Newer techniques for evaluation of retinal disease have been developed and these techniques can detect retinal toxicity earlier.