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    I came across an interesting article, published by the American College of Physicians. It discusses the topic of “autoimmune” diseases, and how many diseases originally thought to be autoimmune diseases are really infectious diseases. IBD is discussed in brief, with reference to both mycobacterial infection and measles infection. You can read it at provides a good overview of medical opinions on many illnesses are changing. By the time the diagnosis is suspected or made, it is often at an advanced stage. Liver cell Adenoma Cholangiocarcinoma Dysplastic Nodule (Macroregenerative Nodule) Hepatocellular carcinoma Hepatoblastoma Atypical Bile Duct Adenoma, Clear Cell Type A Previously Undescribed Tumor of the Liver Jorge Albores-Saavedra, M. The absence of an extrahepatic primary tumor, the histologic features, the immunohistochemical profile, and the fact that all patients are symptom-free 2 months to 18 years after wedge liver biopsy support the interpretation of atypical clear cell bile duct adenoma. With the exception of Ki-67 reactivity, the 13 conventional bile duct adenomas and the clear cell cholangiocarcinoma had essentially a similar immunohistochemical profile as that of the atypical clear cell bile duct adenomas. One atypical bile duct adenoma displayed luminal immunoreactivity for villin. All three atypical bile duct adenomas expressed cytokeratin (CK) 7, p53 protein, epithelial membrane antigen (EMA), and carcinoembryonic antigen (CEA); they were negative for CK20, vimentin, Hep Par 1, chromogranin, and prostatic specific antigen (PSA) and exhibited less than 10% of Ki-67-positive nuclei. The clear cells of this tumor exhibited greater nuclear atypia and increased mitotic activity. The clear cell cholangiocarcinoma was larger (6.0 cm) and had the tubular pattern of conventional cholangiocarcinoma and an abundant desmoplastic stroma. For comparison, a case of clear cell cholangiocarcinoma and 13 conventional bile duct adenomas were examined.

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