Although not all of these side effects may occur, if they do occur they may need medical attention. Check with your doctor immediately if any of the following side effects occur while taking hydroxychloroquine: Incidence not known Some side effects of hydroxychloroquine may occur that usually do not need medical attention. Side effects plaquenil tablets Hydroxychloroquine monitoring parameters Plaquenil maintenance dosage This isn't scientific, just my sense after 15+ years of Plaquenil. As for depression, I think Plaquenil is actually a mild cortical stimulant, so people usually feel peppier because of it. BUT your elevated ferritin may be indicating an underlying inflammatory process. I just read, and this was news to me, that ferritin is an "acute phase. Side effects include irritability, headache, weakness, hair lightening or loss, stomach upset, nausea, dizziness, muscle pain, rash and itching. Rarely, hydroxychloroquine can affect the bone marrow leading to reduced white blood cells leukopenia or platelets thrombocytopenia and abnormal red blood cells but potentially serious eye toxicity can occur. May 25, 2010 Hi! I think Plaquenil is the cause of my extreme fatigue too. I am not anemic at this time and I get exhausted just trying to get through the day. I have also been on Plaquenil about three months. All of my arthritis swelling and pain are gone, but the fatigue will not let up! Hope things change for you. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects. These side effects may go away during treatment as your body adjusts to the medicine. Plaquenil cause depression Long-Term Side Effects of Plaquenil for Rheumatoid., Hydroxychloroquine Plaquenil Side Effects & Dosage for. Plaquenil acetaminophen interactionPlaquenil side effects gum soresBaseline reading for plaquenil therapy Jul 16, 2018 After several months off of plaquenil, I went back on it, deciding to stick with the 100 mg per day. I have always been very sensitive to meds. Again my fatigue improved and I began to be able to do more. But again- over several months time my anxiety, depression, and sense of distance from personal relationships began to worsen. Plaquenil and Depression/Anxiety - Symptoms and Medical.. Is extreme fatigue a side effect of Plaquenil?. Will you have Stress and anxiety with Plaquenil - eHealthMe. Can Plaquenil cause Major Depression? Complete analysis from patient reviews and trusted online health resources, including first-hand experiences. CONCLUSION Greater scores for depression, as a comorbidity of rheumatoid arthritis, increase the rate of suicidal ideation and depression also can worsen general pain, hardships, treatment denial, and prognosis, as well as cause a faster reduction in quality of life. Severe depression and anxiety, overall itching, pain and stiffness increased instead of decreased First, my mother and sister took plaquenil for lupus with good effect, so I am not just disliking it for no good reason. I also suffer from disabling bipolar disorder. For 25 years, I have gotten hypomanic during spring. Very happy, never depressed.