Chloroquine lysosomal degradation

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  1. VEL_88 Guest

    Chloroquine lysosomal degradation

    In MDA-MB-231 cells, immunolocalization and brefeldin A protein transport blocking studies revealed that there was a propensity for newly synthesized Cx43 to be transported to lysosomes. On the other hand, light and electron microscopic analysis of BICR-M1R cells showed that Cx43 gap junctions were prevalent with a subpopulation of intracellular Cx43 localized to lysosomes.

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    Previously, the autophagy-lysosome pathway and valosin-containing protein VCP, key players of the protein quality control PQC, were shown to regulate SG degradation. The effects of chloroquine as a retinopathic agent, as observed by lysosomal dysfunction and RPE degradation, have been demonstrated in various animal models 21–24. We use the ability of chloroquine to increase pH 25 to both understand the general effects of chloroquine on ARPE-19, and as a model for lysosomal inhibition. Autophagy is an evolutionarily conserved and strictly regulated lysosomal pathway that degrades cytoplasmic material and organelles. Autophagy is activated during stress conditions such as amino acid starvation, unfolded protein response or viral infection.

    Interestingly, lactacystin inhibition of proteosomal degradation in MDA-MB-231 cells resulted in a marked increase in phosphorylated Cx43 at the expense of non-phosphorylated Cx43, and this change corresponded with an increase in “oversized” gap junction plaques. In both cell types, Western blots revealed a notable increase in total cellular Cx43 in response to lysosome inhibitors.

    Chloroquine lysosomal degradation

    Chloroquine - Wikipedia, Chloroquine treatment of ARPE-19 cells leads to lysosome.

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  5. Chloroquine is the drug of choice in the few malaria-endemic areas free of CRPf. Combining chloroquine and proguanil is an option for CRPf when other first-line antimalarials are contraindicated. Dosage should be calculated in terms of the base. The adult chloroquine dose is 300 mg base weekly or in some countries 100 mg base daily.

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    Lysosomes are essential for the degradation of old organelles and engulfed microbes and also play a role in programmed cell death 1. Lysosomotropic agents e.g. chloroquine, accumulate preferentially in the lysosomes of cells in the body. These agents tend to have both lipophilic or amphiphilic compounds with basic moieties. Chloroquine is commonly used to study the role of endosomal acidification in cellular processes 2, 3, such as the signaling of intracellular TLRs. Moreover, Chloroquine inhibits autophagy as it raises the lysosomal pH, which leads to inhibition of both fusion of autophagosome with lysosome and lysosomal protein degradation 4. I am trying to block lysosomal degradation in tubular epithelial cells derived from mice kidneys. To that end, I am treating these cells with 100 micromolar Chloroquine 16hours. chloroquine.

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    Plaquenil (hydroxychloroquine) belongs to a group of medicines called quinolines. Hydroxychloroquine DermNet NZ User Reviews for Hydroxychloroquine to treat Lyme Disease. Hydroxychloroquine Side Effects, Dosage, Uses, and More
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