Chloroquine in cancer therapy a double edged sword of autophagy

Discussion in 'Cheap Chloroquine' started by dreg, 19-Mar-2020.

  1. Alex47 User

    Chloroquine in cancer therapy a double edged sword of autophagy


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    Apr 13, 2009 Therefore, it is difficult to predict if inhibition of autophagy may sensitise resistant tumour cells to cytotoxic therapy. Fact is that autophagy plays a dual role in cancer. Our actual examinations suggest a basal enhanced level of autophagy in highly resistant cancer cells, which might promote growth and therapy resistance. Evidence in favor of autophagy functioning as a tumor suppressor comes mostly from discoveries that inactivation of certain autophagy regulators causes cancer in mice and that some human tumors display loss of these regulators. For example, allelic loss of Becn1 causes increased tumor development in mice 22, 23. Sep 01, 2009 The emerging role of autophagy in cancer is one of a double-edged sword Figure 1B. On the one hand, autophagy enables tumor cells to tolerate stress including a hypoxic microenvironment, starvation and probably some forms of therapy.

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    Chloroquine in cancer therapy a double edged sword of autophagy

    Chloroquine enhanced the anticancer capacity of VNP20009., Autophagy and Its Effects Making Sense of Double-Edged Swords

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  4. The role of autophagy in tumorigenesis is complex and it could be a double-edged sword process, as autophagy defects promote cancer progression in association with various dangerous cellular processes, while functional autophagy enables cancer cell survival under stress and likely contributes to the resistance of treatment.

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    • The Double-edged Sword of Autophagy Modulation in Cancer.
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    Cesses of autophagy is a more preferable approach in cancer therapy, however, and is now under investigation 28. Chloroquine in the Kidney, the Double-Edged Sword of Autophagy The use of chloroquine in combination with other chemo-therapeutic reagents may enhance cancer treatment 8, 29, but normal cells also use autophagy to maintain homeostasis, Jan 01, 2013 Chloroquine in cancer therapy a double-edged sword of autophagy. Kimura T1, Takabatake Y, Takahashi A, Isaka Y. Author information 1Department of Geriatric Medicine and Nephrology, Osaka University Graduate School of Medicine, Osaka, Japan. Combination of ERK and autophagy inhibition as a treatment approach for pancreatic cancer.

     
  5. antiafera Moderator

    Hydroxychloroquine (Plaquenil) is considered a disease-modifying anti-rheumatic drug (DMARD). RA and Hydroxychloroquine How Effective is it for. Hydroxychloroquine - Side Effects, Dosage, Interactions. Hydroxychloroquine - Wikipedia
     
  6. frag123 Well-Known Member

    Buy Prescription Hydroxychloroquine Sulfate Plaquenil. Hydroxychloroquine, generic name for Plaquenil, is commonly used to treat Malaria, Rheumatoid Arthritis, Lupus, and other immune disorders. Hydroxychloroquine is usually taken twice daily with food to minimize stomach upset, but dosing can be different based on diagnosis.

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  7. dobrosyn Well-Known Member

    Plaquenil What You Need to Know - Kaleidoscope Fighting Lupus Plaquenil hydroxychloroquine is a medication most known for its original purpose of treating or preventing malaria, a disease caused by parasites that enter the body through the bite of a mosquito.

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