Tell your doctor and pharmacist about all of your drugs (prescription or OTC, natural products, vitamins) and health problems. You must check to make sure that it is safe for you to take chloroquine with all of your drugs and health problems. Hydroxychloroquine is used for what Pct and hydroxychloroquine mechanism 5 years for plaquenil to leave eye Plaquenil energy level Chloroquine inhibits the action of heme polymerase, which causes the buildup of toxic heme in Plasmodium species. 11 It has a long duration of action as the half life is 20-60 days. 10 Patients should be counselled regarding the risk of retinopathy with long term usage or high dosage, muscle weakness, and toxicity in children. 18 You should know that the 150mg base tablet is the same as the 250mg salt tablet and the 300mg base. tablet is the same as the 500mg salt tablet. It is just two different ways of describing the same thing. Chloroquine can be prescribed for either prevention or treatment of malaria. Chloroquine 2-3 mg/kg lean body weight; usually not more than 250 mg daily. Indications RA, SLE, discoid lupus erythematosus, palindromic rheumatism. Mechanism of Action Unknown; may interfere with with macrophage presentation of antigen to T cells. Contraindications Hypersensitivity to hydroxychloroquine, chloroquine, or 4-aminoquinolines For all uses of chloroquine: WARNING/CAUTION: Even though it may be rare, some people may have very bad and sometimes deadly side effects when taking a drug. Do not start, stop, or change the dose of any drug without checking with your doctor. Chloroquine phosphate mechanism of action Chloroquine - Wikipedia, Medicines for the Prevention of Malaria While Traveling. Chloroquine diphosphate dmemPlaquenil total dose Chloroquine Phosphate. Chloroquine is used to prevent or treat malaria caused by mosquito bites in countries where malaria is common. Malaria parasites can enter the body through these mosquito bites, and then live in body tissues such as red blood cells or the liver. Chloroquine Phosphate - WebMD. Hydroxychloroquine and Chloroquine Phosphate - RheumaKnowledgy. Pharmacology of Chloroquine - YouTube. Chloroquine has a long half-life, which can vary between 74 hours and 50 days, depending on the cumulative dose. The drug can remain in the skin for 6–7 months after the cessation of therapy. Chloroquine dosing. Chloroquine phosphate is dispensed as a 250 mg tablet, which is equivalent to 155 mg chloroquine base. Chloroquine mechanism of drug action and resistance in Plasmodium falciparum. Slater AF1. Author information 1Picower Institute for Medical Research, Manhasset, NY 11030. Quinoline-containing drugs such as chloroquine and quinine have had a long and successful history in antimalarial chemotherapy. Mechanism of Action Chloroquine, a 4-aminoquinoline, is an anti-protozoal agent. The precise mechanism by which chloroquine exhibits activity is not known. Chloroquine, may exert its effect against Plasmodium species by concentrating in the acid vesicles of the parasite and by inhibiting polymerization of heme.