Tamoxifen wikipedia

Discussion in 'Drugs Online' started by Andchir, 02-Sep-2019.

  1. dater XenForo Moderator

    Tamoxifen wikipedia


    Tamoxifen là chất đối kháng receptor của receptor estrogen tại mô ngực thông qua chất chuyển hóa có hoạt tính, hydroxytamoxifen. ở một số mô khác như nội mạc tử cung tamoxifen đóng vai trò chất chủ vận, do đó Tamoxifen đóng vai trò giữa chất chủ vận và chất đối kháng chủ vận. Tamoxifen thường được sử dụng cho liệu pháp nội tiết (kháng-estrogen) trong điều trị ung thư vú ở phụ nữ mãn kinh, và đây cũng là chuẩn điều trị cho phụ nữ mãn kinh mặc dù nhómức chế aromatase cũng thường xuyên được sử dụng. Tamoxifen has rarely caused very serious (possibly fatal) strokes, blood clots in the lungs/legs, and cancer of the uterus. If you are taking tamoxifen to reduce the risk of breast cancer, or if your cancer is limited to the milk ducts (ductal carcinoma in situ-DCIS), then discuss the benefits and risks of taking this medication with your doctor. However, if you are taking tamoxifen to treat breast cancer, then the benefits of taking tamoxifen are greater than the risks of side effects. Get medical help right away if you develop symptoms of a stroke or blood clots in the lungs/legs, such as weakness on one side of the body, slurred speech, sudden vision changes, confusion, shortness of breath, chest pain, or calf pain/swelling. Tell your doctor right away if you develop symptoms of cancer of the uterus, such as unusual changes in your monthly period (e.g., amount or timing of bleeding), unusual vaginal discharge, or pain/pressure below your "belly button" (navel). Show More Tamoxifen is used to treat breast cancer. It is also used to reduce the chances of breast cancer in high-risk patients. This medication can block the growth of breast cancer.

    Zoloft 10 mg Levitra wikipedia Tamoxifen side effects

    Tamoxifen là chất đối kháng receptor của receptor estrogen tại mô ngực thông qua chất chuyển hóa có hoạt tính, hydroxytamoxifen. ở một. Tamoxifen ist ein selektiver Estrogenrezeptormodulator, der als Arzneistoff zur Therapie von Brustkrebs bei Frauen vor der Menopause eingesetzt wird. Tamoxifen Citrate is the citrate salt of an antineoplastic nonsteroidal selective estrogen receptor modulator SERM. Tamoxifen competitively inhibits the binding of estradiol to estrogen receptors, thereby preventing the receptor from binding to the estrogen-response element on DNA.

    Tamoxifen is a SERM (selective estrogen receptor modifier). It acts as an estrogen receptor (ER) antagonist in some tissue (in this case, breasts) and an ER agonist in other tissue (in this case, bone and uterus). It is often used for breast cancer treatment for this reason, as it prevents osteoporosis and the spread of estrogen-sensitive cancer in the breasts and can be combined with Gn RH blockers (either Gn RH antagonists or agonists) for treatment. In other words, tamoxifen acts as an anti estrogen in the breasts but as estrogen in bones and skin. This medication would likely be effective in halting breast growth (as it would prevent estrogen from acting in the breasts), and is already used for the treatment of fibrocystic breasts and breast cancer due to lack of side effects compared to other medications like danazol. It can possibly lower levels of IGF-1 (insulin growth factor 1), but also can lead to higher levels of estrogen in the uterus, which could lead to uterine cancer (though the risks are small). Unlike tamoxifen, raloxifene is an ER antagonist in uterine tissue (lowering the risk for uterine cancer), and has a greater ER affinity in bone. Tamoxifen has been proven to lower fibroglandular and breast volume/density in premenopausal women, and it and other SERMS have been proven to move fat distribution from the butt and central region to the legs. Tamoxifen won't work on hormone-receptor-negative breast cancer. Tamoxifen is available in two forms: a pill taken once a day (brand name: Nolvadex) or a liquid form (brand name: Soltamox). If you dislike pills or you're having trouble swallowing tamoxifen pills, Soltamox can help make it easier to stay on your treatment plan. Most doctors recommend taking tamoxifen at the same time each day. — while you are taking tamoxifen and for 2 months afterward. You should not take tamoxifen if you are breastfeeding, pregnant, trying to get pregnant, or if there is any chance that you could be pregnant. You should use an effective non-hormonal type of birth control — such as condoms, a diaphragm along with spermicide, or a non-hormonal I. Ask your doctor which type of non-hormonal birth control would be best for you. Since its approval in 1998, tamoxifen has been used to treat millions of women and men diagnosed with hormone-receptor-positive breast cancer. While an aromatase inhibitor is the first hormonal therapy medicine choice for postmenopausal women, tamoxifen is the first choice for premenopausal women and is still a good choice for postmenopausal women who can't take an aromatase inhibitor.

    Tamoxifen wikipedia

    PharmaWiki - Tamoxifen, TamoxifenWikipedia

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  5. Raloxifene is a benzothiophene derivative and is structurally distinct from the triphenylethylene SERMs like tamoxifen, clomifene, and toremifene. It is the only benzothiophene SERM to have been marketed. 26

    • Raloxifene - Wikipedia.
    • Zemide C32H37NO8 - PubChem.
    • Selective estrogen receptor modulator - Wikipedia.

    Tamoxifen has rarely caused very serious possibly fatal strokes, blood clots in the lungs/legs, and cancer of the uterus. If you are taking tamoxifen to reduce the risk of breast cancer, or if. Tamoxifen is the oldest of the hormonal therapies, drugs that block the effects of estrogen in the breast tissue. Tamoxifen is approved by the FDA to treat people diagnosed with both early-stage and advanced-stage hormone-receptor-positive breast cancer. Tamoxifen is an antagonist of the estrogen receptor in breast tissue. It has been the standard endocrine anti-estrogen therapy for hormone-positive early breast cancer, although aromatase inhibitors have been proposed for postmenopausal women.

     
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