Chloroquine and brain cancer

Discussion in 'Generic Chloroquine' started by BsGroups, 27-Feb-2020.

  1. welcome User

    Chloroquine and brain cancer


    Now a paper published January 17 in the journal describes a new drug combination that has stabilized Rosendahl's disease and increased both the quantity and quality of her life: Adding the anti-malaria drug chloroquine to her treatment stopped an essential process that Rosendahl's cancer cells had been using to resist therapy, re-sensitizing her cancer to the targeted treatment that had previously stopped working. Along with Rosendahl, two other brain cancer patients were treated with the combination and both showed similar, dramatic improvement.

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    Chloroquine is deposited in the tissues in considerable amounts. In animals, from 200 to 700 times the plasma concentration may be found in the liver,spleen, kidney, and lung; leukocytes also concentrate the drug. The brain and spinal cord, in contrast, contain only 10 to 30 times the amount present in plasma. Chloroquine sensitizes breast cancer cells to chemotherapy independent of autophagy. Maycotte P1, Aryal S, Cummings CT, Thorburn J, Morgan MJ, Thorburn A. Chloroquine CQ is a 4-aminoquinoline drug used for the treatment of diverse diseases. Summary. Chloroquine is an anti-malarial drug available at pharmacies for people traveling to area with malaria risks. Note based on a RGCC chemosensitivity analysis I have seen at a German clinic, Hydroxychloroquine has been effective in killing the cancer cells of 5 out 7 patients that were tested.

    They tested it for cancer and it came back positive," Lisa says. "When I was 21 they found a large mass in my brain and I had it resected right away.

    Chloroquine and brain cancer

    Malaria Drug, Chloroquine, May Help Treat Brain Cancer, The Chloroquine Story in Cancer Continues In the Pipeline

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  4. University of Colorado Cancer Center study shows that anti-autophagy drug, chloroquine, used in malaria, can resensitize some brain cancer patients to therapy. AURORA, Colo PRWEB January 12, 2017 After her brain cancer became resistant to chemotherapy and then to targeted treatments, 26-year-old Lisa Rosendahl’s doctors gave her only a few.

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    Jan 20, 2017 The anti-malaria drug chloroquine has now been used as a last resort on three brain cancer patients, and in each case, it seems to have overcome the cancer's resistance to traditional treatments. After her brain cancer became resistant to chemotherapy and then to targeted treatments, 26-year-old Lisa Rosendahl's doctors gave her only a few months to live. Because chloroquine has. SIGNIFICANCE Autophagy inhibition may improve cancer therapy, but it is unclear which tumors will benefi t. We found that BRAF mutations cause brain tumor cells to depend on autophagy and display selective chemosensitization with autophagy inhibition. We present a pediatric case in which deliberate

     
  5. fserges Moderator

    Plaquenil (hydroxychloroquine) belongs to a group of medicines called quinolines. Mint-Hydroxychloroquine - Uses, Side Effects, Interactions. Hydroxychloroquine MedlinePlus Drug Information Hydroxychloroquine Prices, Coupons & Patient Assistance.
     
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    Plaquenil Hydroxychloroquine Sulfate - Sanofi PLAQUENIL can prolong the PR, QRS and QTc intervals, especially in patients with underlying risk factors. Serious adverse events, including fatal outcomes, have been reported in patients taking PLAQUENIL including ventricular arrhythmias, heart blocks, ventricular fibrillation and

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