I took the drug as a treatment for sarcoidosis and one of the side effects is a reduction in white blood cells, which is what has happened to me. Plaquenil is used in the treatment of sarcoidosis but its main use is in the treatment of malaria. Can plaquenil cause vertigo Plaquenil and edema Hydroxychloroquine immune suppressant RARE side effects. If experienced, these tend to have a Severe expression. Abnormal Liver Function Tests. Acute Liver Failure. Acute Pustular Eruptions On Skin. Bronchospasm. Decreased Blood Platelets. Decreased White Blood Cells. More in Eye Health. If you are taking Plaquenil to treat an inflammatory condition or malaria, you should be aware of the side effects that may occur to your eyes and vision. Plaquenil hydroxychloroquine is in a class of drugs called disease-modifying anti-rheumatic drugs, which are used to decrease inflammation, pain and joint damage. Check with your doctor immediately if any of the following side effects occur Incidence not known. Blistering, peeling, loosening of the skin blurred vision or other vision changes chest discomfort, pain, or tightness cough or hoarseness dark urine decreased urination defective color vision diarrhea difficulty breathing For the four years that I took the drug, my eye sight never bothered me and bi-annual eye tests revealed no changes. One of the side effects of taking the drug is that it affects eye sight, and eye tests, especially tests need to be done every six months. Side effects discontinuing plaquenil Hydroxychloroquine Side Effects, Dosage, Uses, and More, Plaquenil Side Effects on Your Eyes and Vision I have lupus am allergic to plaquenil substituteTaking baseline eye examination before starting plaquenil If you arent already, split your doses up and take it with food. It may help your stomach issues. Im glad you are not stopping the plaq. Also, after a few weeks of being on it again your stomach issues may go away. This is a common side effect but usually subsides once your body adjusts to the medication. xoxox Stopping plaquenil. DailyStrength. Hydroxychloroquine Oral Route Side Effects - Mayo Clinic. Side effects to Stopping Plaquenil. - Sarcoidosis - Inspire. That said, my doctor had originally prescribed for me to take 100mg/day for one week and then increase to 200mg/day. When I increased to 200mg/day, I had strange side effects that caused me to go back to 100/day. Strange leg cramping, restless leg, nausea and anxiety. In a nutshell, at 200mg/day the side effects outweighed the benefits. Some side effects may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects. Jan 11, 2012 Incidentally, I asked him why plaquenil causes hair loss, and he said no one knows why. It's just one of those drugs known to have that side effect. Nothing to really help it he said, other than taking folic acid, b12 and biotin. I asked him about methotrexate, and he said he was on it for years for his RA and never had any major side effects from it.