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It affects the entire body and creates permanent changes to the body and the skin. Permanently changing your body is a huge decision and should not be entered into lightly. : ACCUTANE (ISOTRETINOIN) CAUSES SEVERE BIRTH DEFECTS AND FETAL DEATH. Accutane (isotretinoin), or Roaccutane as it is known in parts of the world, was discovered in 1979 when it was first given to patients with severe acne, most of whom reacted with dramatic and permanent clearing of their acne symptoms. It is a vitamin A derivative (13-cis-retinoic acid) that is administered orally in pill form with a meal that contains an adequate amount of fat, This practice is controversial because Accutane is a systemic medication that affects every bodily system and can cause lifelong side effects to the user. 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Eat healthy foods, stay hydrated, and of course, wash your hands! But when you prepare for it, you’ll be able to get out and explore sooner, with fewer problems. Much like giving birth, it’s difficult to describe to someone who hasn’t experienced it. It’s a real thing, caused when our sleep-wake cycle (circadian rhythm) gets disrupted. Some folks are simply more prone to it–I’m one of them. You can prepare, but won’t understand it until it happens. The more time zones we cross–starting with three–the worse it gets. There’s also evidence that dehydration and the reduced amount of oxygen during the flight can be factors. When I first started to fly long distances, I was convinced that jet lag was simply mind-over-matter. Finally, I had to face the fact that I can reduce it, but not avoid it. For a more detailed medical explanation, click here. Jet lag is always an east-west or west-east condition. It doesn’t happen when we fly north or south, because there aren’t changes in daylight or darkness. There are some easy ways to dodge jet lag, starting by leaving home well-rested. This content has not been reviewed within the past year and may not represent Web MD's most up-to-date information. To find the most current information, please enter your topic of interest into our search box. " July 8, 2009 -- Accutane won't be sold any more, drug giant Hoffmann-La Roche Inc. Generic versions of the acne drug, called isotretinoin, are still available from several manufacturers. But Roche, which has sold the drug to 13 million patients since 1982, will not be one of them. The decision was made for "business reasons," Roche announced in a news release. Those reasons include declining sales: Accutane sales now make up less than 5% of the isotretinoin market. Another big reason: Personal injury lawsuits, which Roche is aggressively defending. 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