ABSTRACT QUESTION One of my patients is a pregnant woman in her first trimester with a history of recurrent genital herpes. She is concerned about whether use of her antiviral medication will adversely affect her baby. ANSWER Studies have shown that the use of acyclovir or valacyclovir is not associated with an increase in birth defects. Limited data exist for famciclovir and therefore it would not be considered a first-line choice for treatment of herpes during pregnancy. QUESTION L'une de mes patientes enceintes en est à son premier trimestre de grossesse et elle a des antécédents d'herpès génital récurrent. Elle se demande si l'utilisation de ses médicaments antiviraux pourrait nuire à son bébé. RPONSE Des études ont démontré que l'utilisation de l'acyclovir ou du valacyclovir n'est pas associèe à une augmentation des anomalies congénitales. Les données concernant le famciclovir sont limitées et ce médicament ne devrait donc pas étre considéré comme choix de traitement de première intention pour l'herpès durant la grossesse. Neonatal HSV infections are considered more serious compared with adult infections, having consequences that include the following: skin, eye, and mouth infections; central nervous system diseases; disseminated infections; and death. Hi, I am 38 years old and just found out I am pregnant. About a week after estimated conception, I came down with shingles on my scalp. I didn't know I was pregnant and was prescribed Valtrex at 1 gram twice a day (2 grams total a day) for 7 days. I took the medication for the 7 days and about a day after stopping it I discover I am pregnant. I am beside myself that I might have harmed this baby. I know it is pregnancy category B but I took a pretty high dose and the first trimester is so fragile! Zoloft gas Valacyclovir and breastfeeding Buy accutane online forum This sheet talks about exposure to acyclovir or valacyclovir in a pregnancy or while breastfeeding. This information should not take the place of. One of my patients is a pregnant woman in her first trimester with a history of. of acyclovir, famciclovir, and valacyclovir during pregnancy is relatively lacking. Background The antiviral agents acyclovir Zovirax, valacyclovir Valtrex, and famciclovir Famvir are commonly used to treat initial and. This content has not been reviewed within the past year and may not represent Web MD's most up-to-date information. To find the most current information, please enter your topic of interest into our search box. 24, 2010 -- Taking certain antiviral medications for herpes infections during the first three months of pregnancy does not increase a child's risk of major birth defects, researchers report in this week's issue of the Journal of the American Medical Association. The antiviral drugs acyclovir, valacyclovir, and famciclovir are often prescribed to treat herpes viral infections, such as herpes simplex virus (HSV). More than one in five pregnant women have antibodies in their blood to HSV, indicating a past or present infection. Herpes antiviral medications are also used to treat herpes zoster infections, commonly known as shingles. Until now, information about the safety of these antivirals during pregnancy has been limited, according to background information in the journal article. The medications are listed as category B by the FDA. Benefit should outweigh risk AU TGA pregnancy category: B3US FDA pregnancy category: BComments: -Acyclovir (aciclovir) has been safely used to treat genital herpes in women in all stages of pregnancy; data on prenatal exposure to this prodrug is limited, however, animal data suggests low risk. -Women who acquire genital herpes simplex virus (HSV) during late pregnancy should be managed in consultation with maternal-fetal medicine and infectious-disease specialists. -Suppressive therapy late in pregnancy has been shown to reduce the frequency of cesarean delivery among women with recurrent genital herpes by diminishing the frequency of recurrences at term; such treatment may not protect against transmission to neonates in all cases. -Recommended regimen for HSV suppressive therapy in pregnant women with recurrent genital herpes: 500 mg orally 2 times a day starting at 36 weeks gestation. Animal studies have failed to reveal evidence of teratogenicity for either valacyclovir (valaciclovir) or acyclovir (aciclovir; the active metabolite). No significant neonatal toxicity or fetal drug accumulation was noted in a small pharmacokinetic study (n=20) of this drug (500 mg twice daily) administered beginning at 36 weeks' gestation. Pregnancy registry data reported 1 document exposures to this drug or any formulation of its active metabolite, respectively, of which 29 and 756 exposures occurred in the first trimester. Exposure did not indicate an increased incidence of major birth defects compared with the general population in a prospective pregnancy registry; however, there is insufficient data for definitive conclusions regarding exposure during pregnancy. Valtrex pregnant Use of acyclovir, valacyclovir, and famciclovir in the first trimester of., The Hospital for Sick Children - Safety of antiviral medication for the. Propranolol dosage for dogsWhat bacteria does doxycycline treat Medscape - Herpes simplex, zoster-specific dosing for Valtrex valacyclovir, frequency-based adverse effects, comprehensive interactions, contraindications, pregnancy & lactation schedules, and cost information. Valtrex valacyclovir dosing, indications, interactions, adverse.. Acyclovir Safe for Treating Herpes Infection in Early Pregnancy - AAFP. Valacyclovir During Pregnancy and Breastfeeding. Hi, I am 38 years old and just found out I am pregnant. About a week after estimated conception, I came down with shingles on my scalp. I didn't. The antiviral drugs acyclovir, valacyclovir, and famciclovir are often. More than one in five pregnant women have antibodies in their blood to. Valtrex showed no effects on the fetus in animal studies; however, there has been no adequate evaluation of valacyclovir or acyclovir in pregnant women. The incidence of birth defects in women taking acyclovir is about the same as in the general population.