Dosage of Metformin HCI must be individualized on the basis of both effectiveness and tolerance but should not exceed 2550 mg/ day. Metformin HCl 500 mg Tablet: Usual starting dose: 500 mg every 12 hours, given with or after meals Dosage increases should be made in increments of 500 mg every week, given in divided doses up to a maximum of 2000 mg/day. Metformin HCl 850 mg Tablet: Usual starting dose: 850 mg once a day, given with or after meals Dosage increases should be made in increments of 850 mg every other week, given in divided doses, up to a maximum of 2550 mg/day. Usual maintenance dose: 850 mg twice a day, with or after meals. When necessary, patients may be given 850 mg three times a day with meals. Dosage can also be increased from 500 twice a day to 850 mg twice a day after 2 weeks. For those patients requiring additional glycemic control, Metformin HCI may be given to a maximum daily dose of 2550 mg per day. Treatment of type 2 diabetes mellitus ,particularly in overweight patients, when dietary management and exercise alone does not result in adequate glycaemic control. • In adults,metformin 850mg tablets may be used as monotherapy or in combination with other oral anti-diabetic agents, or with insulin. • In children from 10 years of age and adolescents, Metformin tablets may be used as monotherapy or in combination with insulin. A reduction of diabetic complications has been shown in overweight type 2 diabetic patients treated with metformin as first-line therapy after diet failure (see 5.1 pharmacodynamic properties). Adults: Adults with normal renal function (GFR≥ 90 m L/min) Monotherapy and combination with other oral antidiabetic agents: • The usual starting dose is one tablet 2 or 3 times daily given during or after meals. After 10 to 15 days the dose should be adjusted on the basis of blood glucose measurements. A slow increase of dose may improve gastrointestinal tolerability. 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