Chloroquine cancer 2015

Discussion in 'Plaquenil' started by DiamondTRON, 07-Mar-2020.

  1. hodder Moderator

    Chloroquine cancer 2015


    Chloroquine has been extensively used in mass drug administrations, which may have contributed to the emergence and spread of resistance. It is recommended to check if chloroquine is still effective in the region prior to using it.

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    Chloroquine CQ is a well known, well tolerated medication that has been used for many years traditionally for arthritis, lupus, and malaria. It has anti-inflammatory properties but is often the drug of choice for arthritis and malaria due to its few side effects. Chloroquine's potential chemosensitizing and radiosensitizing activities in cancer may be related to its inhibition of autophagy, a cellular mechanism involving lysosomal degradation that minimizes the production of reactive oxygen species ROS related to tumor reoxygenation and tumor exposure to chemotherapeutic agents and radiation. Antagonistic effects of chloroquine on autophagy occurrence potentiate the anticancer effects of everolimus on renal cancer cells A Grimaldi1,y, D Santini2,y, S Zappavigna1, A Lombardi1, G Misso1, M Boccellino1, V Desiderio3, P P Vitiello3, G Di Lorenzo4,

    The Centers for Disease Control and Prevention recommend against treatment of malaria with chloroquine alone due to more effective combinations. In areas where resistance is present, other antimalarials, such as mefloquine or atovaquone, may be used instead.

    Chloroquine cancer 2015

    The Utility of Chloroquine in Cancer Therapy., NCI Drug Dictionary - National Cancer Institute

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  6. Key words included 'chloroquine', 'cancer', and 'autophagy'. The publication date was up to June 2015. RESULTS Chloroquine mainly executes its anti-tumor function through inhibition of autophagy. It can accumulate inside the lysosome resulting in lysosomal membrane permeabilization LMP which will eventually lead to apoptosis.

    • The utility of chloroquine in cancer therapy..
    • Antagonistic effects of chloroquine on autophagy occurrence potentiate..
    • Chloroquine-based hybrid molecules as promising novel chemotherapeutic..

    Chloroquine is the drug of choice for preventing and treating acute forms of malaria caused by P. vivax, P. malariae, P. ovale, as well as sensitive forms of P. falciparum. The mechanism of its action is not completely clear, although there are several hypotheses explaining its antimalarial activity. Oct 01, 2018 The excretion of Chloroquine and the major metabolite, desethylChloroquine, in breast milk wasinvestigated in eleven lactating mothers following a single oral dose of Chloroquine 600 mg base. The maximum daily dose of the drug that the infant can receive from breastfeeding was about 0.7% of the maternal start dose of the drug in malaria chemotherapy. Herein, we report results of administration of rapamycin, a specific inhibitor of the mechanistic target of rapamycin mTOR signaling pathway, and chloroquine, a lysosomal inhibitor which reverses autophagy by accumulating in lysosomes, responsible for blocking autophagy in 20-month old VCPR155H/+ mice.

     
  7. maxbell Well-Known Member

    Applies to chloroquine: oral tablet Along with its needed effects, chloroquine may cause some unwanted effects. Plaquenil What You Need to Know - Kaleidoscope Fighting Lupus Plaquenil – RheumInfo Plaquenil Uses, Dosage & Side Effects -
     
  8. bus XenForo Moderator

    Malaria is an entirely preventable and treatable disease if tackled early enough. Malaria biology and disease pathogenesis insights for new. Antimalarial Drugs – Malaria Site Chloroquine phosphate REEF2REEF Saltwater and Reef.
     
  9. PiterBerkut New Member

    Plaquenil Uses, Dosage & Side Effects - Apr 10, 2019 Plaquenil is also an antirheumatic medicine and is used to treat symptoms of rheumatoid arthritis and discoid or systemic lupus erythematosus. Important information Taking Plaquenil long-term or at high doses may cause irreversible damage to the retina of your eye.

    Hydroxychloroquine vs Placebo for Patients With.
     
  10. bl3 Well-Known Member

    Plaquenil & Your Eyes Plaquenil is usually used for long term disease control, rather than in the short term to control active bursts of inflammation. Plaquenil has important but uncommon side effects that may affect your eye. How does Plaquenil affect your eyes?

    Hydroxychloroquine Side Effects, Dosage, Uses, and More