Hydroxychloroquine dose adjustment

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  1. SeeDr XenForo Moderator

    Hydroxychloroquine dose adjustment


    -Suppressive therapy should continue for 8 weeks after leaving the endemic area. Approved indication: For the suppressive treatment of malaria due to Plasmodium vivax, P malariae, P ovale, and susceptible strains of P falciparum CDC Recommendations: 300 mg base (500 mg salt) orally once a week Comments: -For prophylaxis only in areas with chloroquine-sensitive malaria -Prophylaxis should start 1 to 2 weeks before travel to malarious areas; should continue weekly (same day each week) while in malarious areas and for 4 weeks after leaving such areas.

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    With the new guidelines for HCQ dosing it becomes imperative for rheumatologists to assess the weight of their patients and adjust the dose of HCQ downward if the patient weights 80 kg. References 1. Recommendations on Screening for Chloroquine and Hydroxychloroquine Retinopathy 2016 Revision. Usual Adult Dose for Amebiasis 1 g chloroquine phosphate 600 mg base orally once a day for 2 days, followed by 500 mg chloroquine phosphate 300 mg base orally once a day for at least 2 to 3 weeks Dosing Adjustments For Goal INR 2.5-3.5 INR 1.5 consider a booster dose of 1 ½ -2 times daily maintenance dose; consider resumption of prior maintenance dose if factor causing decreased INR is transient eg missed warfarin doses if adosage adjustment is needed, increase maintenance dose by 10%–20%.

    Approved indication: For acute attacks of malaria due to P vivax, P malariae, P ovale, and susceptible strains of P falciparum CDC Recommendations: Chloroquine-sensitive uncomplicated malaria (Plasmodium species or species not identified): 600 mg base (1 g salt) orally at once, followed by 300 mg base (500 mg salt) orally at 6, 24, and 48 hours Total dose: 1.5 g base (2.5 g salt) Comments: -For the treatment of uncomplicated malaria due to chloroquine-sensitive P vivax or P ovale, concomitant treatment with primaquine phosphate is recommended. 60 kg or more: 1 g chloroquine phosphate (600 mg base) orally as an initial dose, followed by 500 mg chloroquine phosphate (300 mg base) orally after 6 to 8 hours, then 500 mg chloroquine phosphate (300 mg base) orally once a day on the next 2 consecutive days Total dose: 2.5 g chloroquine phosphate (1.5 g base) in 3 days Less than 60 kg: First dose: 16.7 mg chloroquine phosphate/kg (10 mg base/kg) orally Second dose (6 hours after first dose): 8.3 mg chloroquine phosphate/kg (5 mg base/kg) orally Third dose (24 hours after first dose): 8.3 mg chloroquine phosphate/kg (5 mg base/kg) orally Fourth dose (36 hours after first dose): 8.3 mg chloroquine phosphate/kg (5 mg base/kg) orally Total dose: 41.7 mg chloroquine phosphate/kg (25 mg base/kg) in 3 days Comments: -Concomitant therapy with an 8-aminoquinoline compound is necessary for radical cure of malaria due to P vivax and P malariae.

    Hydroxychloroquine dose adjustment

    Hydroxychloroquine Plaquenil Dosing Calculator - MDCalc, Chloroquine Dosage Guide with Precautions -

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  5. Initial dose 400 mg 310 mg base orally 1 to 2 times a day; this dose may be continued for several weeks or months, depending on patient response Maintenance dose 200 to 400 mg 155 to 310 mg base orally daily

    • Hydroxychloroquine Dosage Guide with Precautions -.
    • Warfarin maintenance dosing nomogram Anticoagulation..
    • Hydroxychloroquine dosage recommendations often ignored MDedge..

    Hydroxychloroquine breaks down into two pharmacologically active metabolites — desethyl-hydroxychloroquine and desethyl-chloroquine. After a single dose, hydroxychloroquine is excreted mainly in the faeces, and only 20% is excreted unchanged in the urine. Dose adjustment is therefore only required in patients with severe renal impairment. Then, 200 to 400 mg taken as a single dose or in two divided doses once a day. Your doctor may adjust your dose if needed. However, dose is usually not more than 600 mg or 6.5 mg per kilogram kg of body weight per day, whichever is lower. Children—Use and dose must be determined by your doctor. For treatment of lupus Appropriate studies performed to date have not demonstrated geriatric-specific problems that would limit the usefulness of hydroxychloroquine in the elderly. However, elderly patients are more likely to have age-related kidney problems, which may require caution and an adjustment in the dose for patients receiving this medicine. Breastfeeding

     
  6. zup Guest

    The page you are trying to reach is not available on our site. The page name may have changed, you may have happened upon a broken link, or the URL may be entered incorrectly. Hydroxychloroquine Sulfate - an overview ScienceDirect Topics Hydroxychloroquine Professional Patient Advice - Hydroxychloroquine Sulphate - Hydroxychloroquine Sulfate.
     
  7. ra-port Guest

    Chloroquine has long been used in the treatment or prevention of malaria from Plasmodium vivax, P. malariae, excluding the malaria parasite Plasmodium falciparum, for it started to develop widespread resistance to it. Chloroquine - FDA prescribing information, side effects and uses Chloroquine hydrochloride - DrugBank Chloroquine Dosage Guide with Precautions -
     
  8. corsair_net XenForo Moderator

    On the Mechanism of Chloroquine Resistance in Plasmodium. In this study we formulate an analytical model describing different combinations of the two sets of hypotheses described below, the first related to the mode of chloroquine binding to HM, the second to the mechanism of action of the mutated PfCRT.

    Mode of Action of Chloroquine - Malaria Home Page
     
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