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    However, most people require weeks or months of doses before they recognize substantial or lasting benefits, in the uncommon cases of a patient receiving such benefits in the first place. On one hand, Zoloft is always working as soon as you take it—within the first minutes and hours, it is causing dysfunction in your brain and body, whether it is your first dose or fiftieth or three hundredth. In an even smaller subset of patients, there is an immediate reaction in the way of efficacy, however. Though some people experience mania, euphoria, or other acute drug effects which can be mistaken for an improvement in an underlying difficulty, a few people experience the same drug effects that longer term users speak of when they have positive things to say about antidepressants. For those people, a few minutes, hours, or in less common cases a few days, are all it takes to go from their pre-drugged state to a potentially sustainable therapeutically drugged state. This subset of people may sometimes be at greater risk of antidepressant tolerance, but I think the factors are too plural to make a generalization. Based on what you said, the most likely explanation is that you were experiencing antidepressant withdrawal symptoms that were alleviated by the reintroduction of Zoloft. It is an exceptional outcome, to have immediate and sustained efficacy, but it happens here and there. If reinstatement helps someone with their withdrawal symptoms, it tends to be quite quickly—within 1–3 days, and oftentimes with the very first dose, even if it is lower than the last dose they were taking on a regular basis.“My mood is combative, I've lost energy, sleep is hard to come by and I have no motivation what so ever.” is an extremely common characterization of SSRI withdrawal symptoms. How long do you have to take Zoloft before it works? - Addiction Blog cipro cf Can Zoloft sertraline work instantly? I took a half a dose 12. How Long Does It Take For Zoloft To Work or "Kick In.
     
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