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Tamoxifen vs aromatase inhibitors

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  1. trikster New Member

    Tamoxifen vs aromatase inhibitors


    Exemestane differs in that its structure is steroidal in nature, and it irreversibly inhibits the aromatase enzyme. These agents are indicated for first- and second-line hormonal therapy in postmenopausal women with hormone receptor–positive breast cancer. Randomized clinical trials comparing 5 years of each of the aromatase inhibitors with 5 years of tamoxifen have demonstrated superior survival rates in postmenopausal women receiving the aromatase inhibitor. Recent randomized trials have also demonstrated additional survival benefits in women who receive 5 years of therapy with an aromatase inhibitor following an initial 5 years of tamoxifen therapy.. Aromatase inhibitor site of activity in the steroidogenic pathway. Common adverse effects include nausea, vomiting, arthralgias/myalgias, and hot flashes. Aromatase inhibition prevents biologic conversion of androstenedione to estrone and testosterone to estradiol. There are high rates of osteopenia/osteoporosis in women receiving aromatase inhibitors (as well as those receiving tamoxifen therapy). As a result, women prescribed these therapies require calcium and vitamin D supplementation, and some may be receiving bisphosphonate therapy for prevention/treatment of osteoporosis. The primary end-point was fatty liver disease and the secondary end-points included abnormal liver function and treatment failure during the 3-year follow up. buy ventolin inhaler asda ) has been the most popular choice as – to put it technical words we’ll explain – “adjuvant therapy for post-initial treatment, early-stage breast cancer that is estrogen receptor positive.” Basically, it helps prevent breast cancer from coming back. You may have heard, however, that recent research may indicate that in post-menopausal women, a class of drugs called aromatase inhibitors (AI) may be effective for preventing breast cancer from coming back. There are indeed some positive benefits that aromatase inhibitors may have over tamoxifen such as less serious side effects, which means they might be easier for you to take. The AIs seem to have lower rates of breast cancer recurrence, which is what you want. That said, they are significantly more expensive, so new we don’t know enough about their long term side effects, and haven’t yet shown any benefit. A possible reason that they haven’t been shown to have survival benefits is that the trials to date simply haven’t been long enough for that data to happen. Additionally, some of the studies found them superior to the degree that participants were switched off tamoxifen, meaning there wasn’t good comparison data.

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    Synthetic Aromatase Inhibitors. The main problem with synthetically produced AIs is the fact that they have unpleasant side effects. A research study done at Princess Margaret Hospital in Toronto compared AIs to Tamoxifen in post-menopausal women. zoloft creativity Curr Opin Oncol. 2005 Nov;176559-65. Choosing between an aromatase inhibitor and tamoxifen in the adjuvant setting. Morales L1, Neven P, Paridaens R. What about if only uterus has been removed and the overies are still there! Can she still take Tamoxifen.Thanks.

    I need to know if Tamoxifin can be given to a person who had a mastectumy. The person is 74 years old and had her overies and uterus removed at the gae of 56. The person can not take Femera anymore because of sever side effect of join and muscle pain. Sue Young55 is correct that tamoxifen is usually used in premenopausal women with hormone-receptor positve BC, who are then switched to an AI when they complete menopause. The surgery was done in January and the person took Femera and since a few weeks ago the medication was switched to "Aromestane" and still severe side effects. But you are also correct that it can also be used in post-menopausal women, esp. Here is a summary of the current recommendations of the American Society of Clinical Oncologists: "To lengthen disease-free survival and lower risk for recurrence (i.e., locoregional or distant recurrence or contralateral breast cancer), postmenopausal women with hormone receptor–positive breast cancer should consider an AI, either as primary adjuvant therapy for 5 years or sequentially after 2 to 3 years of tamoxifen to yield a total of 5 years of adjuvant endocrine therapy. Women who discontinue initial AI therapy before 5 years should consider using tamoxifen to bring the total duration of adjuvant therapy to 5 years. Women who have completed 5 years of adjuvant tamoxifen therapy can benefit from switching to an AI. This extended therapy should not exceed 5 additional years. Long-term exposure to estradiol is associated with an increased risk of breast cancer, but the mechanisms responsible are not firmly established. The prevailing theory postulates that estrogens increase the rate of cell proliferation by stimulating estrogen receptor (ER)-mediated transcription, thereby increasing the number of errors occurring during DNA replication. An alternative theory suggests that estradiol is metabolized to quinone derivatives, which directly remove base pairs from DNA through a process called depurination. Error-prone DNA repair then results in point mutations. We postulate that both processes act in an additive or synergistic fashion. If correct, aromatase inhibitors would block both processes, whereas antiestrogens would only inhibit receptor-mediated effects. Accordingly, aromatase inhibitors would be more effective in preventing breast cancer than antiestrogens.

    Tamoxifen vs aromatase inhibitors

    Hormone Therapy for Breast Cancer American Cancer Society, Choosing between an aromatase inhibitor and tamoxifen in the. - NCBI

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  3. A fact sheet that describes types of hormone therapy, its role in preventing and treating breast cancer, and possible side effects.

    • Hormone Therapy for Breast Cancer Fact Sheet - National Cancer.
    • Tamoxifin vs. Aromatase Inhibitors ! - Breast Cancer -
    • Aromatase inhibitors 'significantly reduce breast cancer deaths'

    Expert Rev Anticancer Ther. 2010 Aug;1081239-53. doi 10.1586/era.10.54. Early recurrence risk aromatase inhibitors versus tamoxifen. Bria E1, Carlini P. can buy viagra shoppers drug mart Accordingly, aromatase inhibitors would be more effective in preventing breast cancer than antiestrogens. Our initial studies showed thatThe tamoxifen plus anastrozole had more breast tumors than did the anastrozole alone. If tamoxifen is a partial agonist that is how we would explain. Aromatase inhibitors work by blocking the enzyme aromatase, which turns the hormone androgen into small amounts of estrogen in the body. Aromatase inhibitors tend to cause fewer serious side effects than tamoxifen, such as blood clots, stroke, and endometrial cancer.

     
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