I was started on Zoloft 5 weeks ago at 50 mg and was doing great at week 4 - at that time Zoloft was increased to 75 mg and I have been taking that dose for 7 days and I feel agitated and anxious. I am not sure how long I should give the dose increase side effects to go away or just go back to taking 50 mg, I was doing very well on 50 mg. I called my mental health facility but there is not a nurse there today. The Pharmacist there had no answers and my appointment with the NP isn't until June the 18th. I know it takes 6 to 8 weeks to really get into your system and I expected side effects when I first started Zoloft but am not sure about these side effects after 7 days going from 50 to 75 mg - Agitation, anxiety, skin burning from the inside out, etc. I am also taking 300 mg of gabapentin 3 times a day, vistaril, and klonopin. Overall, I have had an extremely positive experience with it. Any replies are appreciated, thanks =) Hi,my name is Kristie I was on Zoloft about 10 year's ago, was on it about a year I quit because of a few side effects the main one was no sex drive....almost lost my boyfriend because of it!!! Was off depression meds until 3 years ago when I got diagnostics with stage 4 breast cancer. Whenever the dosage was adjusted, I would notice some side effects. clonidine indication WARNING: SUICIDAL THOUGHTS AND BEHAVIORS Antidepressants increased the risk of suicidal thoughts and behavior in pediatric and young adult patients in short-term studies. Closely monitor all antidepressant-treated patients for clinical worsening, and for emergence of suicidal thoughts and behaviors. In addition to the contraindications for all ZOLOFT formulations listed above, ZOLOFT oral solution is contraindicated in patients taking disulfiram. ZOLOFT oral solution contains alcohol, and concomitant use of ZOLOFT and disulfiram may result in a disulfiram-alcohol reaction. 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